Fcy : : Fur gene was fused by two genes, Fcy and Fur. Gene Fcy encodes yeast cytosine deaminase and gene Fur encodes uracil phosphoribosyltransferase. Fcy::Fur基因由Fcy和Fur两个基因融合而成,其中,Fcy编码酵母菌胞嘧啶脱氨酶,Fur编码尿嘧啶磷酸核糖转移酶。
BACKGROUND & AIM : To observe the expression of yeast cytosine deaminase ( YCD ) gene labeled by RFP in HeLa cells and how it mediates cytotoxicity. 背景与目的:探讨红色荧光蛋白标记的酿酒酵母菌胞嘧啶脱氨酶(YCD)基因在人宫颈癌细胞(HeLa细胞)中的表达及其功能。
Objective : To explore therapeutic effect of a novel yeast cytosine deaminase ( YCD ) suicide gene in vivo on P388 / DBA murine leukemia model. 目的:以P388/DBA小鼠白血病模型,探讨新型自杀基因YCD的体内治疗作用。