Skewed X Chromosome Inactivation and Imprinted / X-linked Gene Expression in Human Embryonic Stem Cells 人类胚胎干细胞X染色体倾斜性失活及印迹、X连锁基因表达状态
Independent clonal origin of multiple uterine leiomyomas that was determined by X chromosome inactivation and microsatellite analysis X染色体失活(XCI)和微卫星分析确定多发性子宫平滑肌瘤的独立克隆来源
It has profound effects on biological processes in mammals, including gene expression and developmental regulation, differentiation, genomic imprinting, X chromosome inactivation and biological defense etc.. 研究表明,DNA甲基化对哺乳动物中诸多生物学过程有着深刻的影响,可能参与基因的表达调控,发育调节,细胞分化,基因组印迹,X染色体灭活和生物防御等。
Methylation and demethylation of DNA are the complementary processes of epigenetic regulation. Methylation and demethylation influence a diverse array of cellular activities, including X chromosome inactivation, genomic imprinting, chromatin modification, and the silencing of endogenous genes. DNA甲基化与去甲基化是表观遗传调控的两种重要调节方式,其在X染色体失活(XCI)、基因组印迹、染色质修饰和内源性基因沉默等过程中发挥重要作用。
Although recent experiments have demonstrated normal reprogramming of telomere length and X chromosome inactivation, epigenetic information established during gametogenesis, such as gametic imprints, cannot be restored after nuclear transfer. 尽管最近的实验证明,端粒长度和X-染色体灭活等程序再编正常,但于配子发生期间形成的后成性信息(如配子基因印迹)在核移植之后并不能恢复。