Death domain of receptors which initiates apoptosis 引发细胞凋亡受体的死亡结构域
By designing four primers for an overlapping PCR, we created a fusion gene Ddl cat encoding human TNF receptor I death domain and chloramphenicol acetyltransferase ( CAT ). 通过设计4个引物进行重叠(overlapping)PCR,由此克隆了人肿瘤坏死因子受体I死亡域(DD)(Deathdomain)与氯霉素乙酰转移酶(CAT)的融合蛋白基因(DdLcat)。
Estrogen protects brain from ischemic injury by suppressing Fas-associated death domain 雌激素抑制Fas相关死亡结构域蛋白保护缺血性脑损伤
BACKGROUND : At present, the study on Fas-associated death domain ( FADD ) and Fas - associated phosphatase-1 ( FAP-1 ) is less, and particularly their expression in ischemic cerebra still remains unclear. 背景:目前对Fas有关的死亡区蛋白(Fas-associateddeathdomainpro-tein,FADD)、Fas有关的磷酸酶(Fas-associatedphosphatase-1,FAP-1)研究较少,尤其它们在脑缺血再灌注中的表达情况尚不清楚。
FADD ( Fas-associated death domain protein ) and caspase-8, especially, play an important role in many apoptotic pathways modulated by death receptors. 其中FADD和Caspase-8在多条死亡受体介导的凋亡途径中起着关键作用。Daxx则在基因转录和细胞凋亡两方面发挥重要作用。