Rearrangements of the mixed lineage leukemia gene in acute myeloid leukemia 急性髓性白血病混合谱系白血病基因重排的研究
Objective To characterize the morphological feature of mixed lineage leukemia ( MLL ) gene related leukemia, and determine the correlation of MLL rearrangements with FAB subtypes. 目的通过观察混合系白血病(MLL)(MixedLineageLeukemia,MLL)基因相关白血病患者骨髓细胞形态学特征,了解MLL基因重排特征与FAB形态学分型的关系。
R bands by heating using Giemsa ( RHG ) banding technique was used for karyotype analysis. mixed lineage leukemia ( MLL ) rearrangement was detected by interphase fluorescence in situ hybridization ( FISH ) using dual color MLL probe in 10 cases. 采用双色混合谱系白血病(MLL)基因探针和间期荧光原位杂交(FISH)技术,对其中10例AL进行MLL重排检测;