The Hepatitis C virus ( HCV ) is an RNA virus that replicates with a high rate of mutation, which is particularly evident in the hyper-variable region 1 ( HVR1 ) of the N-amino terminal region of the second envelope domain of the viral genome. 丙型肝炎病毒(HCV)是一种高突变率的RNA病毒,在病毒基因组E2区的HVR1区,这种高突变率尤为显著。