Most amino acid mutations in RdRp protein localized on protein surface with good accessibility, which could not affect the RdRp protein tertiary structure and active center. RdRp蛋白中可变氨基酸主要位于可及性较好的蛋白分子表面,氨基酸的突变一般不影响蛋白质的三级结构和酶活性中心。
Surface imprinting technology has attracted considerable attention for its accessibility of recognition sites and kinetic properties. 其中表面印迹技术由于识别位点的可接近性和快速达到吸附平衡等特点受到了人们的大量关注。