Considering that the traditional multi decomposition algorithm is easy to get into partial optimization solution, and not overall optimization solution, the study deign hybrid heuristic algorithm to solve the location routing problem model of picking-delivery as a whole. 由于传统的多级分解算法易陷入局部最优解,而不是全局最优。因此,本文从整体上设计混合启发式算法求解一体化配送与集货的定位-运输路线安排问题。