The dominant negative inhibitors discussed earlier as possible treatments could be useful forms of protective antigen to choose. 而前面讨论过的具医疗可行性的显性无效抑制因子,则可以选做有用的保护性抗原。
Study of Signal Transduction Mediated by Integrin α IIb β 3 Using a Dominant Negative(DN) Model 利用显性阴性(DN)模型对整合素αIIbβ3介导的信号转导的初步研究
Objective To investigate the effect on assembly of HBV particle in S gene dominant negative mutant. 目的探讨S基因突变对HBV病毒颗粒组装的影响。
Conclusion Dominant negative mutants of core protein can efficiently suppress wt-HBV replication and the expressions of HBV antigens. 结论在细胞内表达显性阴性(DN)突变体具有干扰HBV复制及抑制HBV抗原表达的作用;
The data indicated that the mutation of LIF did not have a dominant negative effect but lost the biological functions, suggesting that the 29th amino acid is critical for maintaining the activities of LIF. 而29位氨基酸突变的LIF因子则完全丧失了以上功能,但所发现的突变没有显性负的作用.结果充分说明,LIF中高度保守的29位氨基酸对LIF功能的维持具有重要的作用。