Objective : To structurally analyse and functionally identify the nuclear localization signal ( NLS ) in BRD7 and then study its effect on the subcellular localization of BRD7. 本研究旨在对BRD7的核定位信号(NLS)进行预测、结构分析和功能鉴定,并考察其对BRD7亚细胞定位的影响。
Sequence analysis showed that the deduced protein contained a leucine zipper and a possible nuclear localization signal domain. DNA序列分析表明,其编码产物含有一个亮氨酸拉链结构域和一个核定位信号(NLS)肽。
Additionally, it contains a nuclear localization signal ( NLS ) and rich regulation protein motif. 它还具有转录因子核定位信号(NLS)和丰富的调节蛋白基序。
Advances in research on nuclear localization signal 核定位信号(NLS)的研究进展
C-Abl can shuttle between the cytoplasm and the nucleus mediated by three NLSs ( nuclear localization signal ) and one NES ( nuclear export signal ) in its C-terminal domain. c-Abl借助其C端的3个核定位信号(NLS)(NLS)和1个核输出信号(NES)完成细胞核-细胞质间的穿梭过程。