In four CML patients after allo-PBSCT, one had Ph chromosome positive and bcr / abl fusion gene positive, and he had survived up to 70 months after donor lymphocyte infusion and interferon treatment. 4例慢性髓细胞白血病(CML)经alloPBSCT后,Ph染色体和bcr/abl融合基因阳性1例,经供者淋巴细胞输注加干扰素治疗,已生存70个月。
Results The engrafted Flk1 + CD34-cells carrying Bcr / Abl fusion gene from the bone marrow of CML patients can differentiate to the leukemia cells, it can be detected the Bcr / Abl fusion gene positive cells from the bone marrow of receptor mice. 结果植入的CML患者骨髓源BCR/ABL+、Flk1+CD34-细胞在受体小鼠体内分化为白血病细胞,受体小鼠骨髓细胞中存在Bcr/Abl融合基因阳性细胞。
Two cases with Ph chromosome negative but bcr / abl fusion gene positive, and they had survived 2 ~ 27 months. Ph染色体阴性bcr/abl融合基因阳性2例,最长生存27个月。
Clinical Features of bcr / abl Fusion Gene Positive Children with Acute Lymphoblastic Leukemia bcr/abl融合基因阳性急性淋巴细胞白血病的临床特点
Effects of bcr / abl mRNA Antisense Oligonucleotides on Ph Positive Chronic Myelogenous Leukemia Cells bcr/AblmRNA反义寡核苷酸对慢性粒细胞白血病Ph~+细胞的作用