Recently, more and more research in mouse models of neural-tube defects indicated that nearly all of the genes involved in planar cell polarity ( PCP ) pathway play an important role in neural tube closure. 近年来,通过对神经管畸形小鼠的研究表明,平面细胞极化信号通路(Planarcellpolarity,PCP)中的基因的敲除对神经管的闭合起到重要作用。