Objective To investigate the feasibility of inducing anti-osteosarcoma immunity with reducing tumor antigen peptide dose by dentritic cell ( DC ) modified by heat shock protein ( HSP70 ) and osteosarcoma antigen peptide. 目的使用热休克蛋白70(HSP70)和骨肉瘤肽修饰树突状细胞(dentriticcell,DC),研究其作用规律,探讨通过DC提呈途径降低肿瘤抗原肽用量诱导抗骨肉瘤免疫的可行性。
Objective To investigate the feasibility of reduction in tumor antigen peptide dose by dendritic cell ( DC ) presenting so as to elucidate the characteristics of modifying DC by heat shock protein ( Hsp70 ) and antigen peptide. 目的探讨通过树突状细胞(DC)提呈途径降低肿瘤抗原肽用量的可行性,了解热休克蛋白70(Hsp70)和抗原肽修饰DC作用的特点。
OBJECTIVE : Animal model with Alzheimer disease was established to observe the changes in the levels of NO, nitric oxide synthase ( NOS ) and acetylcholinesterase ( AChE ) treated with acidic peptide of various dose concentration. 目的:建立阿尔茨海默病动物模型,观察给予不同剂量浓度的酸性肽治疗后大鼠脑一氧化氮、一氧化氮合酶与乙酰胆碱酯酶含量的变化。
Patients with IDDM received a xenotransplantation of microencapsulated neonatal pig islets by laparoscopic procedure. The change in blood glucose level, C peptide and the dose of insulin used were observed before and after the xenotransplantation. 采用腹腔镜技术,对3例Ⅰ型糖尿病患者进行微囊新生猪胰岛异种移植治疗,观察移植前后空腹血糖、C肽和胰岛素用量的变化。
Results TM-TNF - α mimic peptide displayed on phages can dramatically inhibit the growth of tumor ( P0.01 ) in a dose dependent manner. 结果噬菌体展示TM-TNF-α模拟肽在体内能明显抑制肿瘤的生长(P0.01)。