Objective To evaluate enhancement effect of tumor with specific MR contrast agent Gd-DTPA-HAb18.Materials and Methods After prepared Gd-DTPA HAb18, the average number of Gd coupled with antibody and binding capacity of immunocompetence were measured. 目的评价特异性MR对比剂Gd-DTPA-单克隆抗体HAb18对肿瘤的强化效果。
Fluorescent analysis was further used to test the antibody functions, which showed the binding capacity of the 2 secretion defect antibody were significantly weaker than normal secretion antibodies. 运用免疫荧光检测抗体的功能发现,无分泌能力的抗体,其中和抗原的能力也明显弱于正常分泌的抗体。
Single-chain antibody is superior to monoclonal antibody in tumor diagnosis and treatment, because of their small molecular weights, low immunogenicity, strong tissues penetration force, and good specific binding capacity with tumor. 单链抗体由于分子量小,免疫原性低,组织穿透力强,特异性好等优点,与单克隆抗体相比,在肿瘤的诊断和治疗方面展示了更好的应用前景。