Ataxia Telangiectasia ( AT ) as a genetic disorder results from single gene mutation, characterized by radiosensitivity, progressive nerve degeneration, immunodeficiency, premature aging and cancer predisposition. 共济失调性毛细血管扩张综合症(AT)是一种单基因突变引起的遗传性疾病,表现为高辐射敏感性、进行性神经退变、免疫缺陷、早衰及易患癌症等。