Different from protease and reverse transcriptase, the integrase has no counterpart in mammalian body, thus it has a better selectivity. 这是因为与蛋白酶和逆转录酶不同,整合酶在哺乳动物体内没有同源蛋白,因此有着更好的选择性。
Objective Analysis of drug resistance mutations in the protease and reverse transcriptase gene and in the protease substrate cleavage sites of HIV-1 from AIDS pediatric plasma samples after long term treatment with protease and reverse transcriptase inhibitors for long time. 目的观察接受联合抗病毒治疗获得性免疫缺陷综合征(AIDS)患儿人类免疫缺陷病毒(HIV)的蛋白酶、逆转录酶及蛋白酶切割位点的耐药基因变异。
But compared to the protease inhibitors and reverse transcriptase inhibitors, the designment of HIV-1 integrase inhibitors is relatively slow. 但相对于蛋白酶和逆转录酶,整合酶抑制剂的开发较为缓慢。
Among un-treated MSM in Zhengzhou, all samples displayed susceptible to both protease inhibitors and reverse transcriptase inhibitors. 4. 郑州市男男同性恋中,未接受治疗的艾滋病感染者对蛋白酶抑制剂和逆转录酶抑制剂均未产生耐药。
Delavirdine is indicated in combination with protease inhibitors and nucleoside reverse transcriptase inhibitor for the treatment of HIV-infection. 抗HIV新药地拉韦定是一种非核苷类的逆转录酶抑制剂,是由法玛西亚普强公司研制开发的。