Evaluation of the Pathogenicity of a Field Isolate of Marek ′ s Disease Virus Integrated with Retroviral Long Terminal Repeat(LTR) Sequence 一株整合有禽反转录病毒长末端重复序列的马立克氏病病毒野毒株的致病性研究
A lot of repeat sequences, including insert sequences, tandem repeat sequences and long terminal repeat, were predicted, which might be the result of adaption to new environment or the insertion and deletion of gene on a large scale. 预测发现该菌株具有大量的插入序列、串联重复序列和长末端重复序列,其中插入序列的存在暗示该菌株在进化过程中发生了大规模的基因片段插入与缺失。
Retrotransposons are a class of mobile genetic elements that are particularly abundant in plant genomes. Retrotransposons can be divided into two major groups : the long terminal repeat ( LTR ) and the non-LTR retrotransposons. 植物反转录转座子是植物基因组中一类可移动的遗传元件,可分为LTR反转录转座子和非LTR反转录转座子两类。
Previous studies showed the long terminal repeat ( LTR ) of lentivirus has close relation with the ability of virulence and replication. 有研究认为病毒基因组长末端重复序列LTR与病毒的毒力和复制能力直接相关。
Denatured high performance liquid chromatography ( DHPLC ) was used to array the long terminal repeat DNA fragments, and then the nucleotide sequence of LTR was analyzed by automatic sequence meter. 变性高效液相分析和序列测定LTR片段核苷酸序列,对不同株基因序列作同源性的比较分析。