It has been known previously that up-regulation of Twist, a highly conserved basic helix-loop-helix transcription factor, in lung cancer cells can promote epithelial to mesenchymal transition through down-regulation of E-cadherin. 研究表明,Twist蛋白是属于碱性的螺旋-环-螺旋蛋白家族中的高度保守的转录因子,可以通过下调肺癌中上皮钙粘素的表达而促进上皮间质化。
Genome-Wide Analysis of Basic / Helix-Loop-Helix Transcription Factor Family in Rice and Arabidopsis 水稻和拟南芥中碱性/螺旋环螺旋转录因子家族基因组水平分析
Adenovirus E4 promoter-binding protein 4 ( E4BP4 ), a mammalian basic leucine zipper ( bZIP ) nuclear transcription factor, was identified to be involved in cell survival and proliferation. 腺病毒E4启动子结合蛋白-4(E4BP4)是哺乳动物细胞核内的一种碱性亮氨酸拉链(bZIP)型转录因子,参与调控细胞的存活和增殖。
In this thesis we start with basic biologic knowledge, introduce DNA structure genes and transcription factors, and use the TF working mechanism to show the transcription factor binding sites prediction method. 本文从生物学的基本知识开始介绍,介绍了DNA的结构、基因的组成以及转录因子作用的机理,并通过对转录因子作用机理的分析指出对转录因子结合位点的预测方法。