PC hydrolyzed by actived PLD involves in many important cell events such as cell proliferation, cell division, calcium mobilization, protein kinase activation, etc. PLD激活后水解PC与细胞的许多事件包括细胞增殖、细胞分裂、钙动员、特异的蛋白激酶激活等有关。
The Heidelberg researchers have shown that brain cells which are driven to permanent abnormal cell division by a defective BRAF gene slowed down growth after treatment with kinase inhibitor sorafenib. 海德堡的研究人员已通过试验证实由于BRAF基因缺陷而被导致永久性异常分裂的大脑细胞,经激酶抑制剂索拉菲尼处理后,生长速度明显降低。