CREB binding protein ( CBP ) is a crucial transcriptional coactivator, which contains highly conserved sequence and can interact with about 300 kinds of transcription factors, and is considered to be the key point of the regulation of mammalian genes transcription. CREB结合蛋白(CBP)(cAMPresponseelementbindingproteinbindingprotein,CBP)是一种重要的转录辅激活因子,具有高度保守的序列,能够与300多种转录因子相结合,被认为是哺乳动物基因转录调控中的关键位点。
CREB ( cAMP response element binding protein ), as a transcription factor, activates learning and memory related genes and plays a role in the long term memory ( LTM ). CREB能激活与学习记忆密切相关的基因,在长时记忆(LTM)过程中起重要作用。
Objective To investigate the effects of lovastatin on renal function, activity and expression of the p38 mitogen-activated protein kinase ( MAPK ) and cAMP responsive element - binding protein ( CREB ) in experimental diabetic nephropathy in rats. 目的探讨洛伐他汀对糖尿病(DM)大鼠肾小球结构、功能及肾组织p38丝裂原活化蛋白激酶(MAPK)及其下游转录因子cAMP反应元件结合蛋白(cREB)表达的影响。
Objective : To investigate the effect of calcitonin gene-related peptide ( CGRP ) on the expression of cyclic AMP response element binding protein ( CREB ) and phosphorylated-CREB in rat hippocampus during focal cerebral is - chemia / reperfusion ( I / R ). 目的:探讨外源性降钙素基因相关肽(CGRP)对局灶性脑缺血再灌注大鼠海马CREB和磷酸化CREB(p-CREB)表达的影响。
Recent studies showed that tyrosinase is mainly regulated by microphthalmia-associated transcription factor ( MITF ), which expression is regulated by upstream proteins such as cAMP response element binding protein ( CREB ). 近年研究发现,酪氨酸酶主要受小眼畸形相关转录因子(MITF)的调控,而MITF的表达又受到上游蛋白如cAMP应答元件结合蛋白(CREB)的影响。