Pemetrexed is a multi-target anti-folate agents, by inhibiting the activity of enzymes which are necessary for folic acid synthesis to inhibit DNA replication and thus inhibit the tumor growth. 培美曲塞是一种多靶点抗叶酸制剂,通过抑制合成叶酸所必需的酶的活性来抑制DNA的复制从而抑制肿瘤生长。
Folic acid is necessary for synthesis of nucleic acids and formation of the heme component of hemoglobin in red Blood cells. 叶酸对核酸的合成及红血球中血红蛋白的血红素的形成来说是必需的。
Folic acid participates in DNA synthesis, DNA methylation and other important physiological processes as a methyl donor. 叶酸是机体内甲基供体,参与DNA合成,DNA甲基化等多个重要生理进程。