Progress in Interactions of Transition Metal ions such as Copper and Zinc with β - Amyloid Peptide Associated with Alzheimer's Disease 铜锌等过渡金属离子与Aβ肽作用研究进展
Amyloid beta protein deposit and its neurotoxicity associated with Alzheimer disease 淀粉样β蛋白沉淀及其神经毒性与阿尔茨海默病
These findings suggest that cerebral inflammation has no direct effect on the early memory impairment in AD.3. After amyloid plaque deposition, cerebral inflammation in the brain of 12-month-old APP / PS1 mice was significantly increased, and highly associated with the impaired spatial learning and memory. 在淀粉样斑块形成之后,12月龄APP/PS1小鼠脑内炎症反应显著增加且与其空间学习、记忆功能障碍密切相关,提示炎症反应在AD学习记忆障碍进展过程中具有重要作用。