Salmonella strains carrying spv gene can inhibit DCs maturation to decrease the proliferation of naive T cells. RAPA can promote DCs maturation and enhance the capability of antigen presentation. 3. 携带spv基因的沙门菌能抑制小鼠DCs的成熟,使之刺激NaiveT细胞增殖的能力下降;RAPA可促进DCs的成熟,增强其抗原提呈能力。