He said the issue with cancer drugs is to find the maximum tolerated dose thats most likely to have an anti-cancer effect. 他说有癌药物的问题是要找出最大容忍剂量,其是最可能的是有一抗癌的影响的。
Result : The maximum tolerated dose of the capsules in mice was 126 7 g / kg. 结果:小鼠口服的最大耐受量(MTD)为126.7g总药材/kg体重。
In this paper, the estimation of the maximum tolerated dose of a drug for phase I clinical trials is investigated. 这篇论文主要研究的是第Ⅰ阶段临床试验中最大耐受剂量(MTD)的估计问题。
Currently, chemotherapy is the main treatment to the hormone-independent prostate cancer, and usually the maximum tolerated dose will be chosen which is based on high-dose chemotherapy. The significant side effects limit its widespread use in the clinic. 目前,化疗是激素非依赖前列腺癌的主要治疗手段,且通常采用以最大耐受量为基础的大剂量化疗方案,由于毒副作用明显,限制了其在临床中的广泛使用。
Acute toxicity test in mice was not found to have acute mortality, and the maximum tolerated dose of drugs were tens or hundreds of times more than the clinical dose. 2. 结果:1.冠心苏合丸系列药材在小鼠急性毒性试验中未发现有急性死亡现象,且药物的最大给药量均超过临床剂量的几十倍甚至几百倍。