Objective Bence Jones(BJ) protein ( BJP ) plays an important role in multiple myeloma ( MM ) renal lesion, we try to study the relation between the characteristics of BJP variable gene and the function of renal tubular-epithelial cell ( TEC ). 目的本周蛋白(BJP)在多发性骨髓瘤(MM)肾损害中起主要作用,本研究试图探讨BJP基因可变区特点与肾小管功能损害的关系。
[ Objective ] To evaluate immunofixation electrophoresis ( IFE ) and to compare it with conventional manual heat test method for detection of Bence Jones(BJ) ( BJ ) protein in nonconcentrated urine. [目的]免疫固定电泳法(IFE)检测非浓缩尿中的本-周氏蛋白,并与传统检测方法(热沉淀反应法)相比较。
Objective To detect the Bence Jones(BJ) proteins in human urine by immunofixation electrophoresis and analyses the clinical diagnosis for the positive patients, discuss its applications in clinical. 目的用免疫固定技术检测尿液本-周蛋白,并对阳性结果患者的临床诊断进行分析,探讨其在临床上的应用。
Conclusions The detection of Bence Jones(BJ) proteins in human urine by immunofixation electrophoresis is specific and sensitive, has great aid in identification of monoclonal gammopathy. 结论用免疫固定电泳法检测尿液本-周蛋白具有特异性和高灵敏度,对M蛋白病的诊断有着重大意义。
The relation between Bence Jones(BJ) protein gene polymorphism and function of renal tubular-epithelial cell in multiple myeloma 多发性骨髓瘤本周蛋白基因可变区特点与肾小管功能损害的关系