The infection efficiency of adenovirus is determined by the levels of CAR and integrin on cancer cells. 肿瘤细胞表面CAR和整合素的表达水平决定了腺病毒(AD)对肿瘤细胞的感染效率。
Objective To construct recombinant adenovirus by homologous recombination in bacteria. 目的通过细菌内同源重组方法构建重组腺病毒(AD)。
Aim of the study is to construct urothelium-specific recombinant adenovirus and investigate its inhibition in bladder cancer cell. 本研究是构建膀胱上皮特异性重组腺病毒(AD),探讨其在膀胱癌细胞中的抑制作用。
Adenovirus is the main candidate for expressing and delivering therapy genes because of its intensive tissue tropism. 因其具有广泛的组织亲和性,腺病毒(AD)成为表达和传递治疗基因的主要候选者。
As the adenovirus can be grown in mammal cells, the method avoids the problems of egg-based production. 由于腺病毒(AD)可以在哺乳动物细胞中生长,这种方法避免了用鸡蛋制取疫苗的问题。